ABSTRACT
Objective Neonatal bronchiolitis is not well characterized. We studied the profile of acute bronchiolitis in term newborns during a respiratory syncytial virus (RSV) surge following relaxation in coronavirus disease 2019 (COVID-19) appropriate behavior.Methods This was a retrospective descriptive study performed in the neonatology division of a tertiary care pediatric hospital at Srinagar, Jammu and Kashmir, India. Term neonates (born at =37 completed gestational weeks) from 7 up to 28 days of life admitted with bronchiolitis over a 1-month period (November 2021) were included.Results Out of total 480 neonatal admissions over a month, 35 (7%) had acute bronchiolitis. Eight neonates were excluded. Out of 27 included neonates, 13 were males. Mean age at presentation was 20 days. All neonates were born at term (=37 completed gestational weeks). Cough (26), rapid breathing (20), and lower chest indrawing (20) were the predominant presenting features. Median SPO2 was 87% (interquartile range 85-92%). Fourteen (52%) neonates needed admission to neonatal intensive care unit. Respiratory support was needed in the form of oxygen through nasal prongs in 24 (89%) newborns. Heated humidified high-flow nasal cannula (HHHFNC) and bubble continuous positive airway pressure were used in five neonates each. Two neonates were mechanically ventilated. The mean duration of the hospital stay was 6.2 days. All neonates survived.Conclusion A series of 27 term neonates with bronchiolitis during an RSV surge is reported in the aftermath of lifting of COVID-19 restrictions. Many of these neonates were sick enough to require significant respiratory support. The outcome was good in all neonates.
ABSTRACT
Purpose: Despite the significant growth in Islamic economies and the increasing number of Muslim youths inclining digital services, empirical-based research addressing the adoption of digital Islamic services is still scarce. Particularly, as a new term in the Islamic finance industry, ZakaTech has recently emerged as a modern term describing novel technologies adopted by zakat (compulsory levy on all believing and practicing high-net-worth Muslims) institutions;yet, it has largely been neglected in the literature. Therefore, this paper aims to propose an integrated model that scrutinizes the factors of unified model of acceptance and use of technology (UTAUT) of ZakaTech, combined with social cognitive theory (SCT), especially in a time of COVID-19 social distancing. Design/methodology/approach: The UTAUT–SCT model was validated via SmartPLS structural equation modeling by using a valid sample of 510 users (individual zakat payers) from Saudi Arabia. Findings: The results demonstrated the suitability of the integrated UTAUT–SCT model in predicting zakat payers' intention to use ZakaTech services. This proposed model has 70% explanatory power to explain variance in intention. All UTAUT constructs are statistically significant, except for effort expectancy. Social isolation caused by the pandemic and trust in e-zakat system exerted a significant influence on the inclination to uptake ZakaTech services. Originality/value: To the best of the authors' knowledge, this research is among the first research that studies Muslims' adoption of ZakaTech during COVID-19. Particularly, this study could add value to FinTech acceptance literature by empirically examining an integrated framework of UTAUT–SCT in a context as modern and unique as ZakaTech. © 2023, Emerald Publishing Limited.
ABSTRACT
Retinal detachment (RD) is a prevalent cause of blindness that is common after ocular injury to military personnel. Permanent vision loss occurs due to death of photoreceptors and formation of excessive scar tissue, known as proliferative vitreoretinopathy (PVR). There are no effective pharmaceuticals to prevent these problems. The inflammatory protein, macrophage migration inhibitory factor (MIF), is produced at high levels in RD and PVR, as well as in excitotoxic (NMDA-mediated) damage, which is important in blast injury. We tested the ability of different clinically-relevant MIF inhibitors to block photoreceptor death after NMDA damage in a chick excitotoxic retinal damage model. These inhibitors, ibudilast, AV1013, and CPSI-1306, are well tolerated in the eye, and treatment with the maximum dose of each drug does not show retinal toxicity. Ibudilast pretreatment significantly reduced the number of TUNEL positive cells in the retina after NMDA damage. CPSI-1306 also reduced TUNEL. AV1013 had no effect. Ibudilast and AV1013 also blocked epithelial mesenchymal transition in the invitro PVR model.
ABSTRACT
Pandemic pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally at an accelerated rate, with an approximate reproductive number of 2–2.5, suggesting that two or three individuals may be infected with index patient cases. Current coronavirus disease 2019 (COVID-19) impact on disadvantaged populations and areas where there are inadequate health services to treat the infection, it is entirely dangerous and triggering serious public health emergencies. This study also highlights the review of COVID-19 for the reopening of Malaysia’s borders and puts together the new draught options for the country’s reopening. Malaysia’s border controls have been tightened to deter imported cases, mitigate locally transmitted cases, and increase the capacity of Malaysian health care facilities. The study has analysed secondary data as the primary input. The aim of this writing is to discuss the potential outbreak of COVID-19 in Malaysia in the event of the national border reopening and the question of COVID-19 protection and security. In order to find the required articles for reference, the literature search was performed throughout Google Scholar. The goal of the study is to express a view that can be seen by tertiary maternity units that are capable of treating those affected by the pandemic, but at the same time ensuring that the people at their heart are safe. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.